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Individualised Selection of Left‐sided Breast Cancer Patients for Proton Therapy Based on Cost‐effectiveness by Annabelle M. Austin; Michael J.J. Douglass; Giang T. Nguyen; Lisa Cunningham; Hien Le; Yvonne Hu; Scott N. Penfold is a Medicine article available to read on EtoBox.
What is Individualised Selection of Left‐sided Breast Cancer Patients for Proton Therapy Based on Cost‐effectiveness about?
## Abstract ## Introduction The significantly greater cost of proton therapy compared with X‐ray therapy is frequently justified by the expected reduction in normal tissue toxicity. This is often true for indications such as paediatric and skull base cancers. However, the benefit is less clear for other more common indications such as breast cancer, and it is possible that the degree of benefit may vary widely between these patients. The aim of this work was to demonstrate a method of individualised selection of left‐sided breast cancer patients for proton therapy based on cost‐effectiveness of treatment. ## Methods 16 left‐sided breast cancer patients had a treatment plan generated for the delivery of intensity‐modulated proton therapy (IMPT) and of intensity‐modulated photon therapy (IMRT) with the deep inspiration breath‐hold (DIBH) technique. The resulting dosimetric data was used to predict probabilities of tumour control and toxicities for each patient. These probabilities were used in a Markov model to predict costs and the number of quality‐adjusted life years expected as a result of each of the two treatments. ## Results IMPT was not cost‐effective for the majority of pati
Who reads Individualised Selection of Left‐sided Breast Cancer Patients for Proton Therapy Based on Cost‐effectiveness?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Annabelle M. Austin; Michael J.J. Douglass; Giang T. Nguyen; Lisa Cunningham; Hien Le; Yvonne Hu; Scott N. Penfold
- Publisher
- Wiley
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)