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Can I read Asymmetric Cyclopropanation of Chiral (1-Dimethoxyphosphoryl-2-phenyl)vinyl P-tolyl Sulfoxide: a New Synthesis of Enantiomerically Pure 2-Amino-3-phenyl-1-cyclopropane-phosphonic Acid—a Constrained Analog of Phaclofen on EtoBox?
Asymmetric Cyclopropanation of Chiral (1-Dimethoxyphosphoryl-2-phenyl)vinyl P-tolyl Sulfoxide: a New Synthesis of Enantiomerically Pure 2-Amino-3-phenyl-1-cyclopropane-phosphonic Acid—a Constrained Analog of Phaclofen by Wanda H Midura; Marian Mikołajczyk is a Chemistry article available to read on EtoBox.
What is Asymmetric Cyclopropanation of Chiral (1-Dimethoxyphosphoryl-2-phenyl)vinyl P-tolyl Sulfoxide: a New Synthesis of Enantiomerically Pure 2-Amino-3-phenyl-1-cyclopropane-phosphonic Acid—a Constrained Analog of Phaclofen about?
E-(S)-(1-Dimethoxyphosphoryl-2-phenyl)vinyl p-tolyl sulfoxide 3 was found to undergo cyclopropanation with sulfur ylides [dimethyl(oxo)sulfonium methylide, diphenyl sulfonium isopropylide and ethyl (dimethylsulfuranylidene)acetate (EDSA)] in a highly diastereoselective manner. The major diastereomer obtained in the reaction of E-(S)-3 with EDSA was converted into enantiopure (2R)-amino-(3R)-phenyl-(1R)-cyclopropane-phosphonic acid, a constrained analog of the GABA B antagonist, phaclofen.
Who reads Asymmetric Cyclopropanation of Chiral (1-Dimethoxyphosphoryl-2-phenyl)vinyl P-tolyl Sulfoxide: a New Synthesis of Enantiomerically Pure 2-Amino-3-phenyl-1-cyclopropane-phosphonic Acid—a Constrained Analog of Phaclofen?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Wanda H Midura; Marian Mikołajczyk
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)
- Published
- 2002
- Language
- EN
- Field
- Chemistry (Physical Sciences)