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Preoperative and postoperative dextromethorphan provides sustained reduction in postoperative pain and patient‐controlled epidural analgesia requirement: A randomized, placebo‐controlled, double‐blind study in lower‐body bone malignancy‐operated patients by Avi A. Weinbroum; Benjamin Bender; Jacob Bickels; Alexander Nirkin; Nissim Marouani; Shoshana Chazam; Isaac Meller; Yehuda Kollender is a Medicine article available to read on EtoBox.

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## Abstract ## BACKGROUND Pain is mediated centrally by __N__‐methyl‐D‐aspartate (NMDA) receptors. The antinociceptive effects of preincision dextromethorphan (DM), an NMDA antagonist, have been demonstrated in surgical patients under general or epidural anesthesia. The authors investigated the effects of DM on postoperative pain and other parameters in patients undergoing surgery for bone malignancy under standardized combined general and epidural anesthesia using patient‐controlled epidural analgesia (PCEA) postoperatively. ## METHODS Patients received placebo or DM 90 mg (30 patients per group) in a double‐blind manner preoperatively and on each of the two following days. Postoperative PCEA consisted of 1.6 mg ropivacaine plus 4 μg/mL fentanyl both continuously and by demand up to 96 hours, starting when subjective pain intensity was greater than or equal to 4/10 (visual analog score). Rescue drugs on demand (paracetamol or dipyrone orally) were also available. ## RESULTS The DM patients experienced about 50% (__P__ < 0.01) less pain than their placebo counterparts for more than 2 postoperative days and they rated their overall maximal pain intensity by one‐half that estimated b

Who reads Preoperative and postoperative dextromethorphan provides sustained reduction in postoperative pain and patient‐controlled epidural analgesia requirement: A randomized, placebo‐controlled, double‐blind study in lower‐body bone malignancy‐operated patients?

Author

Avi A. Weinbroum; Benjamin Bender; Jacob Bickels; Alexander Nirkin; Nissim Marouani; Shoshana Chazam; Isaac Meller; Yehuda Kollender

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2003

Language

EN

Field

Medicine (Health Sciences)