Can I read A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells on EtoBox?

A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells by Park, Sung-Woo; Kim, Joo-Young; Kim, You-Sun; Lee, Sang Jin; Lee, Sang Don; Chung, Moon Kee is a Medicine article available to read on EtoBox.

What is A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells about?

## Purpose Despite most epidemiologic studies reporting that an increase in milk intake affects the growth of prostate cancer, the results of experimental studies are not consistent. In this study, we investigated the proliferation of prostate cancer cells treated with casein, the main protein in milk. ## Materials and Methods Prostate cancer cells (LNCaP and PC3), lung cancer cells (A459), stomach cancer cells (SNU484), breast cancer cells (MCF7), immortalized human embryonic kidney cells (HEK293), and immortalized normal prostate cells (RWPE1) were treated with either 0.1 or 1 mg/mL of α-casein and total casein extracted from bovine milk. Treatments were carried out in serum-free media for 72 hours. The proliferation of each cell line was evaluated by an 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. ## Results α-Casein and total casein did not affect the proliferations of RWPE1, HEK293, A459, SNU484, MCF7, HEK293, or RWPE1 cells. However, PC3 cells treated with 1 mg/mL of α-casein and casein showed increased proliferation (228% and 166%, respectively), and the proliferation of LNCaP cells was also enhanced by 134% and 142%, respectively. The prolifer

Who reads A Milk Protein, Casein, as a Proliferation Promoting Factor in Prostate Cancer Cells?

Author

Park, Sung-Woo; Kim, Joo-Young; Kim, You-Sun; Lee, Sang Jin; Lee, Sang Don; Chung, Moon Kee

Publisher

Korean Society for Sexual Medicine and Andrology (KAMJE); Korean Society for Sexual Medicine and Andrology (ISSN 2287-4208)

Published

2014

Language

EN

Field

Medicine (Health Sciences)