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Can I read Lactate as a metabolite from probiotic Lactobacilli mitigates ethanol-induced gastric mucosal injury: an in vivo study on EtoBox?
Lactate as a metabolite from probiotic Lactobacilli mitigates ethanol-induced gastric mucosal injury: an in vivo study by Huang, Yingpeng (author);Zhang, Jiali (author);Dong, Renjie (author);Ji, Xiawei (author);Jiang, Yusha (author);Cen, Jianke (author);Bai, Zhihuai (author);Hong, Kairui (author);Li, Huihui (author);Chen, Jiajing (author);Zhou, Jinhui (author);Qian, Fanyu (author);Wang, Fangyan (author);Qu, Yue (author);Zhou, Yan (author) is a Medicine article available to read on EtoBox.
What is Lactate as a metabolite from probiotic Lactobacilli mitigates ethanol-induced gastric mucosal injury: an in vivo study about?
## Abstract ## Background Pre-administration of probiotic Lactobacilli attenuates ethanol-induced gastric mucosal injury (GMI). The underpinning mechanisms remain to be elucidated. We speculated that lactate, the main metabolite of Lactobacillus that can be safely used as a common food additive, mediated the gastroprotective effect. This study aimed to gain experimental evidence to support our hypothesis and to shed lights on its underlying mechanisms. ## Methods Lactate was orally administrated to mice at different doses 30 min prior to the induction of GMI. Gastric tissue samples were collected and underwent histopathological and immunohistochemical assessments, enzyme-linked immunosorbent assay, quantitative polymerase chain reaction (qPCR) and western blot analyses. ## Results Pretreatment with lactate at 1–3 g/kg significantly curtailed the severity of ethanol-induced GMI, as shown by morphological and histopathological examinations of gastric tissue samples. Significantly lower level of cytokines indicative of local inflammation were found in mice receiving lactate treatment prior to ethanol administration. Western-blot, immunohistochemical analysis and qPCR suggested that ga
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- Author
- Huang, Yingpeng (author);Zhang, Jiali (author);Dong, Renjie (author);Ji, Xiawei (author);Jiang, Yusha (author);Cen, Jianke (author);Bai, Zhihuai (author);Hong, Kairui (author);Li, Huihui (author);Chen, Jiajing (author);Zhou, Jinhui (author);Qian, Fanyu (author);Wang, Fangyan (author);Qu, Yue (author);Zhou, Yan (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)