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Medium Chain Triglyceride Diet Reduces Anxiety-like Behaviors and Enhances Social Competitiveness in Rats by Fiona Hollis; Ellen Siobhan Mitchell; Carles Canto; Dongmei Wang; Carmen Sandi is a Neuroscience article available to read on EtoBox.

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Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. MCT are converted into ketones and free medium chain fatty acids that, in the brain, are highly effective energy sources to mitochondria and potentially less harmful than glucose metabolism to neurons. Given the recently established link between mitochondrial dysfunction and high anxiety and depression, we performed this study to investigate the effectiveness of an MCT-enriched diet to ameliorate anxiety- and depression-related behaviors in rats. Male rats were distributed into groups, according to their anxiety-like behaviors in the elevated plus maze. Each group was given either MCT-supplemented diet or an isocaloric control diet for fifteen days. Starting from the eighth day of diet, rats were exposed to different behavioral tests. MCT-fed rats exhibited reduced anxiety-like behaviors and enhanced social competitiveness, while their coping responses in the forced swim test were not affected by the treatment. When evaluated at the end of the two-week MCT diet, mitochondrial respiration was reduced in the medial prefrontal cortex (mP

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Author

Fiona Hollis; Ellen Siobhan Mitchell; Carles Canto; Dongmei Wang; Carmen Sandi

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0028-3908)

Published

2018

Language

EN

Field

Neuroscience (Life Sciences)