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Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma by L. G. Sensi; F. Marcucci; E. Migali; G. Coniglio is a Medicine article available to read on EtoBox.
What is Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma about?
**Background:** After allergen exposure, IgE‐bearing mast cells surface in respiratory mucosa. Eosinophils are also recruited locally by chemotactic mediators; they are the main cell directly involved in the late phase of allergic inflammation. IgE antibody and eosinophil cationic protein (ECP) are routinely determined mainly in serum although they exert their pathogenetic role more directly on mucosal surfaces. **Methods:** We performed a comparative study of IgE antibody to grass and ECP on nasal mucosa and blood samples in order to evaluate the relevance of monitoring allergic inflammation in the target organ. Thirty‐one patients and 10 nonatopic controls were enrolled in the protocol. Twenty‐six subjects allergic to grass, 11 with rhinitis (group 1) and 15 with asthma and rhinitis (group 2), completed the study. Five patients dropped out. Specific IgE to grass and ECP was determined in nasal mucosa by our method based on __in situ__ incubation. **Results:** Serum IgE to grass did not increase during the pollen peak, as did nasal IgE, in group 1 from before the pollen peak, from 2.3 to 3.2 kU/l (__P__=0.02), and in group 2 at the pollen peak, from 4.8 to 12.2 kU/l (__P__=0.01).
Who reads Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma?
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- Author
- L. G. Sensi; F. Marcucci; E. Migali; G. Coniglio
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-4538)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)