Can I read Maternal Antioxidant Treatments Prevent Diabetes-induced Alterations of Mitochondrial Morphology in Rat Embryos on EtoBox?

Maternal Antioxidant Treatments Prevent Diabetes-induced Alterations of Mitochondrial Morphology in Rat Embryos by Xiaolin Yang; L.A. Håkan Borg; C. Martin Simán; Ulf J. Eriksson is a Medicine article available to read on EtoBox.

What is Maternal Antioxidant Treatments Prevent Diabetes-induced Alterations of Mitochondrial Morphology in Rat Embryos about?

Previous studies have suggested that production of reactive oxygen species by embryonic mitochondria may have a role in the induction of both high-amplitude mitochondrial swelling and embryonic dysmorphogenesis in diabetic pregnancy. The present study analyzed the relationships between a putative metabolite-induced production of free oxygen radicals, mitochondrial lipid peroxidation, and high-amplitude mitochondrial swelling in embryos during organogenesis. For studies in vitro, day 9 embryos of normal rats were cultured for 48 h with a high concentration of glucose in the absence or presence of ␣-cyano-4hydroxycinnamic acid (CHC), a mitochondrial pyruvate transport inhibitor. The morphology of mitochondria in the neuroepithelium of the embryos was studied with the aid of transmission electron microscopy. For studies in vivo, normal and diabetic pregnant rats were fed a diet supplemented with the antioxidants ␣-tocopherol (vitamin E) or 2,6-di-tert-butyl-4-methylphenol (BHT), and the ultrastructure of mitochondria in the embryonic neuroepithelium and in the visceral yolk sac was investigated on gestational day 11. Exposure to a high concentration of glucose in vitro or to maternal

Who reads Maternal Antioxidant Treatments Prevent Diabetes-induced Alterations of Mitochondrial Morphology in Rat Embryos?

Author

Xiaolin Yang; L.A. Håkan Borg; C. Martin Simán; Ulf J. Eriksson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0003-276X)

Published

1998

Language

EN

Field

Medicine (Health Sciences)