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Terminal versus segmental development in the Drosophila embryo: the role of the homeotic gene fork head by Gerd Jürgens; Detlef Weigel is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Mutations of the homeotic gene fork head filch) of Drosophila transform the non-segmented terminal regions of the embryonic ectoderm into segmental derivatives: Pre-oral head structures and the foregut are replaced by post-oral head structures which are occasionally associated with thoracic structures. Posterior tail structures including the hindgut and the Malpighian tubules are replaced by post-oral head structures associated with anterior tail structures. The Jkh gene shows no maternal effect and is required only during embryogenesis. The phenotypes of double mutants indicate that fkh acts independently of other homeotic genes (ANT-C, BX-C, spalt) and caudal. In addition, thefl~h domains are not expanded in Polycomb (Pc) group mutant embryos. Ectopic expression of the homeotic selector genes of the ANT-C and BJ(-C in Pc group mutant embryos causes segmental transformations in terminal regions of the embryo only in the absence offish gene activity. Thus, fkh is a region-specific homeotic rather than a selector gene, which promotes terminal as opposed to segmental development.

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Author

Gerd Jürgens; Detlef Weigel

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 1432-041X)

Published

1988

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)