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Short Course Radiotherapy Is an Appropriate Option for Most Malignant Glioma Patients by Lawrence Kleinberg; Tanya Slick; Cheryl Enger; Stuart Grossman; Henry Brem; Moody D. Wharam Jr. is a Medicine article available to read on EtoBox.

What is Short Course Radiotherapy Is an Appropriate Option for Most Malignant Glioma Patients about?

Purpose: To determine whether a shortened course of radiotherapy (RT) is an appropriate treatment option for malignant glioma patients. Methods and Materials: Prognostic groups published by the Radiation Therapy Oncology Group (RTOG) are used to compare results for a short radiotherapy regimen with results of aggressive protocol treatment. The studs group includes 219 patients treated during 1975-I-993 with 51 Gy in 17 fractions.-Patients were retrospectively assigned to six prognostic groups previously identified in a recursive partitioning analysis of the RTOG. The prognostic groups are based on age, histology, performance status, mental status, neurologic function, resection extent, length of symptoms, and RT dose. Results: The six RTOG prognostic groupings were significantly predictive of outcome for patients treated with thisshortened regimen (log-rank, p < 0.001) . The median survival for our patients by RTOG groups l-6 were 68,57,22, 13,8, and 5 months, respectively. Two-year survival results were 64,67,45,8,3, and 3%. The median and two-year survival results for each prognostic grouping were similar to the results achieved by aggressive treatment on RTOG malignant glioma tr

Who reads Short Course Radiotherapy Is an Appropriate Option for Most Malignant Glioma Patients?

Author

Lawrence Kleinberg; Tanya Slick; Cheryl Enger; Stuart Grossman; Henry Brem; Moody D. Wharam Jr.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1997

Language

EN

Field

Medicine (Health Sciences)