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BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer by Kan Wang; Jing Ruan; Qirong Qian; Hua Song; Chenchen Bao; Xueqing Zhang; Yifei Kong; Chunlei Zhang; Guohan Hu; Jian Ni; Daxiang Cui is a Engineering article available to read on EtoBox.

What is BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer about?

## Background Gastric cancer is 2th most common cancer in China, and is still the second most common cause of cancer-related death in the world. How to recognize early gastric cancer cells is still a great challenge for early diagnosis and therapy of patients with gastric cancer. This study is aimed to develop one kind of multifunctional nanoprobes for __in vivo__ targeted magnetofluorescent imaging of gastric cancer. ## Methods BRCAA1 monoclonal antibody was prepared, was used as first antibody to stain 50 pairs of specimens of gastric cancer and control normal gastric mucous tissues, and conjugated with fluorescent magnetic nanoparticles with 50 nm in diameter, the resultant BRCAA1-conjugated fluorescent magnetic nanoprobes were characterized by transmission electron microscopy and photoluminescence spectrometry, as-prepared nanoprobes were incubated with gastric cancer MGC803 cells, and were injected into mice model loaded with gastric cancer of 5 mm in diameter via tail vein, and then were imaged by fluorescence optical imaging and magnetic resonance imaging, their biodistribution was investigated. The tissue slices were observed by fluorescent microscopy, and the important org

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Author

Kan Wang; Jing Ruan; Qirong Qian; Hua Song; Chenchen Bao; Xueqing Zhang; Yifei Kong; Chunlei Zhang; Guohan Hu; Jian Ni; Daxiang Cui

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1477-3155)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)