Can I read Novel Interventions to Reduce Oxidative-stress Related Brain Injury in Neonatal Asphyxia on EtoBox?

Novel Interventions to Reduce Oxidative-stress Related Brain Injury in Neonatal Asphyxia by A.L. Solevåg; G.M. Schmölzer; P.-Y. Cheung is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Novel Interventions to Reduce Oxidative-stress Related Brain Injury in Neonatal Asphyxia about?

Perinatal asphyxia-induced brain injury may present as hypoxic-ischemic encephalopathy in the neonatal period, and disability including cerebral palsy in the long term. The brain injury is secondary to both the hypoxic-ischemic event and the reoxygenation-reperfusion following resuscitation. Early events in the cascade of brain injury can be classified as either inflammation or oxidative stress through the generation of free radicals. The objective of this paper is to present efforts that have been made to limit the oxidative stress associated with hypoxic-ischemic encephalopathy. In the acute phase of ischemia/hypoxia and reperfusion/reoxygenation, the outcomes of asphyxiated infants can be improved by optimizing the initial delivery room stabilization. Interventions include limiting oxygen exposure, and shortening the time to return of spontaneous circulation through improved methods for supporting hemodynamics and ventilation. Allopurinol, melatonin, noble gases such as xenon and argon, and magnesium administration also target the acute injury phase. Therapeutic hypothermia, N-acetylcysteine2-iminobiotin, remote ischemic postconditioning, cannabinoids and doxycycline target the

Who reads Novel Interventions to Reduce Oxidative-stress Related Brain Injury in Neonatal Asphyxia?

Author

A.L. Solevåg; G.M. Schmölzer; P.-Y. Cheung

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)