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Perineural Invasion is a Marker for Pathologically Advanced Disease in Localized Prostate Cancer by Irwin H. Lee; Rebecca Roberts; Rajal B. Shah; Kirk J. Wojno; John T. Wei; Howard M. Sandler is a Medicine article available to read on EtoBox.

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## Purpose: To determine if perineural invasion (pni) should be included in addition to prostate-specific antigen (psa), biopsy gleason score, and clinical t-stage for risk-stratification of patients with localized prostate cancer. ## Methods and materials: We analyzed prostatectomy findings for 1550 patients, from a prospectively collected institutional database, to determine whether pni was a significant predictor for upgrading of gleason score or pathologic t3 disease after patients were stratified into low-, intermediate-, and high-risk groups (on the basis of psa, biopsy gleason score, and clinical t-stage). ## Results: For the overall population, pni was associated with a significantly increased frequency of upgrading and of pathologic t3 disease. after stratification, pni was still associated with significantly increased odds of pathologic t3 disease within each risk group. in particular, for low-risk patients, there was a markedly increased risk of extraprostatic extension (23% vs. 7%), comparable to that of intermediate-risk patients. among high-risk patients, pni was associated with an increased risk of seminal vesicle invasion and lymph node involvement. furthermore, ove

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Author

Irwin H. Lee; Rebecca Roberts; Rajal B. Shah; Kirk J. Wojno; John T. Wei; Howard M. Sandler

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)