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Local Diffusion in the Extracellular Space of the Brain by Jan Tønnesen; Sabina Hrabĕtová; Federico N. Soria is a Neuroscience article available to read on EtoBox.

What is Local Diffusion in the Extracellular Space of the Brain about?

The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological complexity, composed of narrow gaps separated by local expansions, enabling interconnected highways between neural cells. Constituting on average 20% of brain volume, the ECS is key for intercellular communication, and understanding its diffusional properties is of paramount importance for understanding the brain. Within the ECS, neuroactive substances travel predominantly by diffusion, spreading through the interstitial fluid and the extracellular matrix scaffold after being focally released. The nanoscale dimensions of the ECS render it unresolvable by conventional live tissue compatible imaging methods, and historically diffusion of tracers has been used to indirectly infer its structure. Novel nanoscopic imaging techniques now show that the ECS is a highly dynamic compartment, and that diffusivity in the ECS is more heterogeneous than anticipated, with great variability across brain regions and physiological states. Diffusion is defined primarily by the local ECS geometry, and secondarily by the viscosity of the interstitial fluid, including the obstructive and binding properties of th

Who reads Local Diffusion in the Extracellular Space of the Brain?

Author

Jan Tønnesen; Sabina Hrabĕtová; Federico N. Soria

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)