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Outpatient Assessment of Residual Growth Hormone Secretion in Treated Acromegaly with Overnight Urinary Growth Hormone Excretion, Random Serum Growth Hormone and Insulin Like Growth Factor‐1 by Vernon J. Parfitt; Daniel Flanagan; Peter Wood; Brian A. Leatherdale is a Medicine article available to read on EtoBox.

What is Outpatient Assessment of Residual Growth Hormone Secretion in Treated Acromegaly with Overnight Urinary Growth Hormone Excretion, Random Serum Growth Hormone and Insulin Like Growth Factor‐1 about?

## OBJECTIVE To assess the outpatient investigations, overnight urinary growth hormone (uGH) excretion, random serum GH and insulin like growth factor 1 (IGF‐1), and GH indices from the oral glucose tolerance test (OGTT) (fasting, nadir and mean GH), as measures of mean GH secretion in treated acromegaly, in comparison with a GH day series, which served as a gold standard. ## DESIGN Prospective cross‐sectional study, with patients admitted to a metabolic ward for the following investigations: random GH, IGF‐1, 6 point GH day series (day 1), 9 h timed overnight uGH excretion, OGTT with GH response (day 2). Agreements between the mean GH during the day series and the other outcome measures, and the diagnostic performance of the latter, for the presence or absence of active acromegaly (mean GH during day series 5 or < 5 mU/l, respectively) were determined. ## PATIENTS 26 patients with treated acromegaly (11 with inactive acromegaly off drug therapy). ## MEASUREMENTS Serum GH and uGH were measured by immunoradiometric assays and IGF‐1 by radioimmunoassay. ## RESULTS Agreements with the mean GH during the day series were perfect for the nadir GH during the OGTT with a 2 mU/l cutoff (Co

Who reads Outpatient Assessment of Residual Growth Hormone Secretion in Treated Acromegaly with Overnight Urinary Growth Hormone Excretion, Random Serum Growth Hormone and Insulin Like Growth Factor‐1?

Author

Vernon J. Parfitt; Daniel Flanagan; Peter Wood; Brian A. Leatherdale

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

1998

Language

EN

Field

Medicine (Health Sciences)