Can I read Association of the Serotonin 2A Receptor rs6311 Polymorphism with Diurnal Preference in Koreans on EtoBox?

Association of the Serotonin 2A Receptor rs6311 Polymorphism with Diurnal Preference in Koreans by Ji Won Yeom; Seunghwa Jeong; Ju Yeon Seo; Sehyun Jeon; Heon-Jeong Lee is a Psychology article available to read on EtoBox.

What is Association of the Serotonin 2A Receptor rs6311 Polymorphism with Diurnal Preference in Koreans about?

## Objective Evidence for the association between circadian rhythm delay and depression is accumulating. Genetic studies have shown that certain polymorphisms in circadian genes are potential genetic markers of diurnal preference. Along with circadian genes, there is a growing interest in other genetic effects on circadian rhythms. This study evaluated whether the __HTR2A__ rs6311 (-1438C/T) polymorphism is associated with diurnal preference in a Korean population. ## Methods A total of 510 healthy subjects were included in this study. All subjects were genotyped for the __HTR2A__ rs6311 polymorphism and they completed the Korean version of the composite scale of morningness (CSM). ## Results The C allele carriers (C/C+C/T) showed significantly higher CSM scores compared to C allele non-carriers (T/T) (t=2.22, p=0.03), suggesting the existence of a morning chronotype tendency in C allele carriers. In other words, the T/T genotype may be associated with the evening chronotype. ## Conclusion These results suggest that the __HTR2A__ rs6311 polymorphism may be associated with diurnal preference in a healthy Korean population. The absence of the C allele may be responsible for the incre

Who reads Association of the Serotonin 2A Receptor rs6311 Polymorphism with Diurnal Preference in Koreans?

Author

Ji Won Yeom; Seunghwa Jeong; Ju Yeon Seo; Sehyun Jeon; Heon-Jeong Lee

Publisher

Korean Neuropsychiatric Association

Published

2020

Language

EN

Field

Psychology (Social Sciences)