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Can I read Time Effects of Food Intake on the Pharmacokinetics and Pharmacodynamics of Quazepam on EtoBox?
Time Effects of Food Intake on the Pharmacokinetics and Pharmacodynamics of Quazepam by Norio Yasui-Furukori; Takenori Takahata; Tsuyoshi Kondo; Kazuo Mihara; Sunao Kaneko; Tomonori Tateishi is a Medicine article available to read on EtoBox.
What is Time Effects of Food Intake on the Pharmacokinetics and Pharmacodynamics of Quazepam about?
**Aims** There is little information on interaction between food and the hypnotic agent quazepam. We therefore studied the effects of food and its time interval on the pharmacokinetics and pharmacodynamics of quazepam. **Methods** A randomized three‐phase crossover study with 2‐week intervals was conducted. Nine healthy male volunteers took a single oral 20 mg dose of quazepam under the following conditions: 1) after fasting overnight; 2) 30 min after eating standard meal; or 3) 3 h after eating the same meal. Plasma concentrations of quazepam and its metabolite, 2‐oxoquazepam and psychomotor function using the Digit Symbol Substitute Test (DSST), Stanford Sleepiness Scale (SSS) and Visual Analogue Scale were measured up to 48 h. **Results** During the food treatments at 30 min and 3 h before dosing, the peak concentrations (__C__~max~) were 300% (95% CI 260, 340%; __P__ < 0.001) and 250% (95% CI 210, 290%; __P__ < 0.01) of the corresponding value during the fasting phase. For quazepam, the area under the plasma concentration–time curve from 0 to 8 h measured at 30 min and 3 h before dosing was significantly increased, with the food treatments by 2.4‐fold (95% CI 2.0; 2.8‐fold; __P
Who reads Time Effects of Food Intake on the Pharmacokinetics and Pharmacodynamics of Quazepam?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Norio Yasui-Furukori; Takenori Takahata; Tsuyoshi Kondo; Kazuo Mihara; Sunao Kaneko; Tomonori Tateishi
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0306-5251)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)