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What is Interpreting LDL Histograms in Biology about?

Researchers studied individuals with mutations in the PCSK9 gene that lowers LDL cholesterol levels. They found that: 1) 85 individuals with an inactivating mutation in one PCSK9 gene copy had lower LDL levels on average compared to 3278 individuals without mutations. 2) 58% of individuals with a mutation had LDL levels below 100 mg/dL, compared to 36% of individuals without mutations. 3) Inactivating PCSK9 mutations are associated with reduced risk of cardiovascular disease due to lower LDL levels.

Author

Michael Allison

Language

EN