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Evolocumab Treatment Reduces Carotid Intima-media Thickness in Paediatric Patients with Heterozygous Familial Hypercholesterolaemia by A Wiegman; A Ruzza; G K Hovingh; R D Santos; F Mach; C Stefanutti; I Luirink; I Bridges; B Wang; A K Bhatia; F J Raal; J J P Kastelein; D Gaudet is a Medicine article available to read on EtoBox.

What is Evolocumab Treatment Reduces Carotid Intima-media Thickness in Paediatric Patients with Heterozygous Familial Hypercholesterolaemia about?

Abstract Background Familial hypercholesterolemia (FH) is characterised by high plasma levels of low-density lipoprotein cholesterol (LDL-C) and increased risk of premature atherosclerotic cardiovascular disease (ASCVD). Previous studies show that carotid intima-media thickness (cIMT) is increased in children with FH, an indicator of early ASCVD. Add-on treatment with the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, evolocumab, substantially reduced atherosclerotic lipid levels in children with heterozygous FH (HeFH) and was safe and well tolerated. The effect of evolocumab on cIMT in paediatric patients (pts) has not been investigated. Purpose To investigate the effect of evolocumab treatment on cIMT progression in paediatric pts with HeFH. Methods HAUSER-RCT was a multicenter, randomised, placebo-controlled study in which paediatric FH pts (ages 10–17 years) received monthly subcutaneous injections of evolocumab 420 mg or placebo. Of 157 pts, 150 continued to an open-label extension study (HAUSER-OLE) during which all received up to 80 weeks of monthly evolocumab 420 mg on top of stable background statin therapy. cIMT was measured by B-mode ultrasound scanning

Who reads Evolocumab Treatment Reduces Carotid Intima-media Thickness in Paediatric Patients with Heterozygous Familial Hypercholesterolaemia?

Author

A Wiegman; A Ruzza; G K Hovingh; R D Santos; F Mach; C Stefanutti; I Luirink; I Bridges; B Wang; A K Bhatia; F J Raal; J J P Kastelein; D Gaudet

Published

2022

Language

EN

Field

Medicine (Health Sciences)