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Sulfadoxine–pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy by D. S. Tarimo; J. N. Minjas; I. C. Bygbjerg is a Medicine article available to read on EtoBox.

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Following widespread chloroquine (CQ) resistance, sulfadoxine plus pyrimethamine (SP) is now the first line antimalarial drug in a number of African countries including Tanzania. Unlike CQ, SP has no antipyretic effects, a feature that might delay fever clearance, and by acting on late stage parasites, SP could theoretical be slow in parasite clearance. We therefore assessed the antipyretic effects of CQ in therapeutic combination with SP, and the speed of parasite clearance by SP in an open‐labelled, randomized trial of CQ alone (__n__=39), SP alone (__n__=39), SP plus CQ (__n__=37) and SP plus paracetamol (PCM) (__n__=38) in children with uncomplicated malaria. Over 72 h, there were eight (20.5%) treatment failures in the CQ group but none in the other groups. Although not significant (__P__ > 0.1), irrespective of resistance CQ alone had a shorter median survival time to fever clearance than SP alone (54 __vs.__ 60 h). SP plus CQ had a highly significantly shorter median survival time to fever clearance than SP alone (48 __vs.__ 60 h) (__P__ < 0.001). Although borderline (__P__=0.038), the median survival time to parasite clearance was significantly longer in SP plus PCM (72 h)

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Author

D. S. Tarimo; J. N. Minjas; I. C. Bygbjerg

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; ScienceOpen (ISSN 1360-2276)

Published

2002

Language

EN

Field

Medicine (Health Sciences)