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Neuropeptide Innervation and Neuroendocrine Cells in Allergic Rhinitis and Chronic Hypertrophic Rhinitis by S.-Y. Fang; C.-L. Shen is a Medicine article available to read on EtoBox.

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## Background: The neuropeptides and neuroendocrine cells are proven to exist in the human nasal mucosa. however, the pathophysiological and neuroimmunological roles of regulatory peptides in human nasal diseases require further investigation. ## Objectives: To investigate and compare the functional morphology and quantify the tissue concentration of regulatory peptides in the nasal mucosas of normal, allergic rhinitis (ar) and chronic hypertrophic rhinitis (chr) subjects. ## Methods: Human inferior turbinate mucosa specimens from 28 patients with ar, 25 patients with chr and 15 patients without any nasal diseases were investigated. using immunohistochemistry and radioimmunoassays, we detected the presence, distribution and concentrations of various neuropeptides (vasoactive intestinal peptides [vip], neuropeptide y [npy], substance p [sp], calcitonin gene-related peptides [cgrp]) and general neuroendocrine markers (neurone-specific enolase, chromogranin a and somatostatin). quantitative analysis of the stained fibres and cells were performed using a graphic autocad program. ## Results: The presence and distribution of npy, cgrp, and sp nerve fibres and neuroendocrine cells were si

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Author

S.-Y. Fang; C.-L. Shen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)

Published

1998

Language

EN

Field

Medicine (Health Sciences)