Can I read Mechanical stretch stimulates integrin αVβ3-mediated collagen expression in human anterior cruciate ligament cells on EtoBox?
Mechanical stretch stimulates integrin αVβ3-mediated collagen expression in human anterior cruciate ligament cells by Tomonori Tetsunaga; Takayuki Furumatsu; Nobuhiro Abe; Keiichiro Nishida; Keiji Naruse; Toshifumi Ozaki is a Medicine article available to read on EtoBox.
What is Mechanical stretch stimulates integrin αVβ3-mediated collagen expression in human anterior cruciate ligament cells about?
Biomechanical stimuli have fundamental roles in the maintenance and remodeling of ligaments including collagen gene expressions. Mechanical stretching signals are mainly transduced by cell adhesion molecules such as integrins. However, the relationships between stress-induced collagen expressions and integrin-mediated cellular behaviors are still unclear in anterior cruciate ligament cells. Here, we focused on the stretch-related responses of different cells derived from the ligament-to-bone interface and midsubstance regions of human anterior cruciate ligaments. Chondroblastic interface cells easily lost their potential to produce collagen genes in non-stretched conditions, rather than fibroblastic midsubstance cells. Uni-axial mechanical stretches increased the type I collagen gene expression of interface and midsubstance cells up to 14- and 6-fold levels of each non-stretched control, respectively. Mechanical stretches also activated the stress fiber formation by shifting the distribution of integrin alphaVbeta3 to the peripheral edges in both interface and midsubstance cells. In addition, integrin alphaVbeta3 colocalized with phosphorylated focal adhesion kinase in stretched ce
Who reads Mechanical stretch stimulates integrin αVβ3-mediated collagen expression in human anterior cruciate ligament cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tomonori Tetsunaga; Takayuki Furumatsu; Nobuhiro Abe; Keiichiro Nishida; Keiji Naruse; Toshifumi Ozaki
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)