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Can I read Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy on EtoBox?
Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy by Kinan Alhallak; Jennifer Sun; Katherine Wasden; Nicole Guenthner; Julie O’Neal; Barbara Muz; Justin King; Daniel Kohnen; Ravi Vij; Samuel Achilefu; John F. DiPersio; Abdel Kareem Azab is a Medicine article available to read on EtoBox.
What is Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy about?
T-cell-based immunotherapy, such as CAR-T cells and bispecific T-cell engagers (BiTEs), has shown promising clinical outcomes in many cancers; however, these therapies have significant limitations, such as poor pharmacokinetics and the ability to target only one antigen on the cancer cells. In multiclonal diseases, these therapies confer the development of antigen-less clones, causing tumor escape and relapse. In this study, we developed nanoparticle-based bispecific T-cell engagers (nanoBiTEs), which are liposomes decorated with anti-CD3 monoclonal antibodies (mAbs) targeting T cells, and mAbs targeting the cancer antigen. We also developed a nanoparticle that targets multiple cancer antigens by conjugating multiple mAbs against multiple cancer antigens for T-cell engagement (nanoMuTEs). NanoBiTEs and nanoMuTEs have a long half-life of about 60 h, which enables once-a-week administration instead of continuous infusion, while maintaining efficacy in vitro and in vivo. NanoMuTEs targeting multiple cancer antigens showed greater efficacy in myeloma cells in vitro and in vivo, compared to nanoBiTEs targeting only one cancer antigen. Unlike nanoBiTEs, treatment with nanoMuTEs did not c
Who reads Nanoparticle T-cell engagers as a modular platform for cancer immunotherapy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kinan Alhallak; Jennifer Sun; Katherine Wasden; Nicole Guenthner; Julie O’Neal; Barbara Muz; Justin King; Daniel Kohnen; Ravi Vij; Samuel Achilefu; John F. DiPersio; Abdel Kareem Azab
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)