Can I read Design, Synthesis and Biological Evaluation of New Substituted Sulfonamide Tetrazole Derivatives as Antitubercular Agents on EtoBox?

Design, Synthesis and Biological Evaluation of New Substituted Sulfonamide Tetrazole Derivatives as Antitubercular Agents by Amaroju Suresh; Narva Suresh; Sunil Misra; Muthyala Murali Krishna Kumar; Kondapalli Venkata Gowri Chandra Sekhar is a Chemistry article available to read on EtoBox.

What is Design, Synthesis and Biological Evaluation of New Substituted Sulfonamide Tetrazole Derivatives as Antitubercular Agents about?

## Abstract The 1,2,4 triazole and tetrazole pharmacophore is still considered a viable lead structure for the synthesis of more efficacious and broad spectrum anti‐microbial agents. In this communication, a new class of highly potent anti‐tuberculosis agents are reported. Designed and synthesized a series of 18 compounds and evaluated them for their anti‐tubercular activity against __Mycobacterium tuberculosis__ H37Rv strain. Among the compounds tested, five compounds exhibited moderate anti‐TB activity (MIC = 6.25 μg/mL); compounds 8a, 8d, 8i, 9b and 9f displayed good activity (Minimal inhibition concentration (MIC) = 3.12 μg/mL), while compounds 8e, 8g, 8h, 9d and 9h exhibited excellent activity (MIC = 1.56 μg/mL) against the growth of __Mycobacterium tuberculosis__ H37Rv. Furthermore, they displayed no toxicity against CHO‐K1 cell lines at a concentration of 100 μM. These investigated analogues have emerged as potential leads to extend the scope of the anti‐tubercular research. Additionally, the most active compounds were docked to enzyme MTB CytP51 (2CIB.pdb) to understand ligand‐receptor binding interactions.

Who reads Design, Synthesis and Biological Evaluation of New Substituted Sulfonamide Tetrazole Derivatives as Antitubercular Agents?

Author

Amaroju Suresh; Narva Suresh; Sunil Misra; Muthyala Murali Krishna Kumar; Kondapalli Venkata Gowri Chandra Sekhar

Publisher

Wiley

Published

2016

Language

EN

Field

Chemistry (Physical Sciences)