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What is ELF5 Modulates The Estrogen Receptor Cistrome in Breast Cancer about?

The research article investigates the role of the ETS transcription factor ELF5 in modulating the estrogen receptor (ER) cistrome in breast cancer, particularly in the context of endocrine resistance. The study reveals that elevated ELF5 levels lead to altered binding patterns of ER and FOXA1, affecting gene expression and contributing to resistance against endocrine therapies. These findings suggest that ELF5 interacts with the ER transcriptional complex and may drive the acquisition of endocrine resistanc

Author

Ran Lin

Language

EN