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Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer by Eva Pastille; Tabea Faßnacht; Alexandra Adamczyk; Nhi Ngo Thi Phuong; Jan Buer; Astrid M. Westendorf is a Immunology and Microbiology article available to read on EtoBox.

What is Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer about?

Patients suffering from ulcerative colitis are at increased risk of developing colorectal cancer. Although the exact underlying mechanisms of inflammation-associated carcinogenesis remain unknown, the intestinal microbiota as well as pathogenic bacteria are discussed as contributors to inflammation and colitis-associated colon cancer (CAC). In the present study, we analyzed the impact of TLR4, the receptor for Gram-negative bacteria derived lipopolysaccharides, on intestinal inflammation and tumorigenesis in a murine model of CAC. During the inflammatory phases of CAC development, we observed a strong upregulation of __Tlr4__ expression in colonic tissues. Blocking of TLR4 signaling by a small-molecule-specific inhibitor during the inflammatory phases of CAC strongly diminished the development and progression of colonic tumors, which was accompanied by decreased numbers of infiltrating macrophages and reduced colonic pro-inflammatory cytokine levels compared to CAC control mice. Interestingly, inhibiting bacterial signaling by antibiotic treatment during the inflammatory phases of CAC also protected mice from severe intestinal inflammation and almost completely prevented tumor grow

Who reads Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer?

Author

Eva Pastille; Tabea Faßnacht; Alexandra Adamczyk; Nhi Ngo Thi Phuong; Jan Buer; Astrid M. Westendorf

Publisher

Frontiers Media SA

Published

2021

Language

EN

Field

Immunology and Microbiology (Life Sciences)