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Mixing Dynamics in USP vs PEAK™ Vessels by Leonardo Klismam is a document available to read on EtoBox.
What is Mixing Dynamics in USP vs PEAK™ Vessels about?
The study compares the dissolution rates of acetaminophen and naproxen sodium tablets using USP Apparatus 2 with standard vessels and PEAK™ vessels. Results indicate that PEAK™ vessels demonstrate improved mixing dynamics and higher drug release rates compared to USP vessels, particularly at higher RPMs. The formation of a cone at the bottom of USP vessels negatively impacts dissolution rates, which is mitigated by the design of PEAK™ vessels.
- Author
- Leonardo Klismam
- Language
- EN