Opening book details…
Can I read A Multiple Chemical Equilibria Approach to Modeling and Interpreting the Separation of Amino Acid Enantiomers by Chiral Ligand-exchange Chromatography on EtoBox?
A Multiple Chemical Equilibria Approach to Modeling and Interpreting the Separation of Amino Acid Enantiomers by Chiral Ligand-exchange Chromatography by Nooshafarin Sanaie; Charles A. Haynes is a Chemistry article available to read on EtoBox.
What is A Multiple Chemical Equilibria Approach to Modeling and Interpreting the Separation of Amino Acid Enantiomers by Chiral Ligand-exchange Chromatography about?
A model of chiral ligand-exchange chromatography (CLEC) is presented that combines the non-ideal equilibrium-dispersion equation for solute transport with equations describing all chemical equilibria within the column. The model connects elution band profiles to the time and space resolved formation of diastereomeric complexes in both the mobile and stationary phases, thereby providing insights into the overall separation mechanism. The stoichiometries and formation constants for all equilibrium complexes formed in the mobile phase are taken from standard thermodynamic databases and independent potentiometric titration experiments. Formation constants for complexes formed with the stationary phase ligand are determined from potentiometric titration data for a water-soluble analogue of the ligand. Together this set of pure thermodynamic parameters can be used to calculate the equilibrium composition of the system at any operating condition. The model includes a temperaturedependent pure-component parameter, determined by regression to a single elution band for the pure component, that corrects for subtle effects associated with immobilizing the ligand (i.e., the chiral selector) ont
Who reads A Multiple Chemical Equilibria Approach to Modeling and Interpreting the Separation of Amino Acid Enantiomers by Chiral Ligand-exchange Chromatography?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Nooshafarin Sanaie; Charles A. Haynes
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)