About this Engineering article

Improvement of Sticking Tendency of Granules During Tabletting Process by Pressure Swing Granulation by Noor Fitrah Abu Bakar; Ajit Mujumdar; Shun Urabe; Katsura Takano; Kazuo Nishii; Masayuki Horio is a Engineering article available to read on EtoBox.

A novel binderless coating method was developed to eliminate the sticking problem during tabletting process for the granules of a drug powder of high stickiness by using Pressure Swing Granulation (PSG) technique. PSG was applied to a mixture consisting of 70 wt.% milled lactose and 30 wt.% milled Ibuprofen (IBP) at an ambient temperature for the production of core granules and further coated with 2 wt.% fine lactose particles at 70 °C. These coated granules were compacted (at 199 MPa) in a tabletting machine to obtain tablets of 8 mm diameter. It was found that the coated layer of lactose particles on the granules was capable of blocking the migration of sublimated IBP during heating and coating. This was further verified experimentally by characterizing a one-dimensional system of an artificially coated granule (a lactose-IBP layer sandwiched in between two layers of lactose) using a microscope mapping technique of Raman spectroscopy. In a sample size of 200 tablets per batch, only 2% of the tablets were found to be sticking to the tabletting machine with the damaged area in the range of 1-10% of the total surface area of the tablet. Overall, PSG technique was found to be success

Author

Noor Fitrah Abu Bakar; Ajit Mujumdar; Shun Urabe; Katsura Takano; Kazuo Nishii; Masayuki Horio

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0032-5910)

Published

2007

Language

EN

Field

Engineering (Physical Sciences)