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Elevated Pulmonary Arterial Elastance And Right Ventricular Uncoupling Are Associated With Greater Mortality In Advanced Heart Failure by Wright, Stephen P.; Groves, Leah; Vishram-Nielsen, Julie K.K.; Karvasarki, Elizabeth; Valle, Felipe H.; Alba, Ana C.; Mak, Susanna is a Medicine article available to read on EtoBox.

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## Background: The objectives of this study were to describe right ventricular-pulmonary arterial elastance coupling hemodynamic phenotypes and their frequency in patients with advanced heart failure and to evaluate the association of elastance-based indices with all-cause mortality, cardiac transplantation, and left ventricular assist device therapy. ## Methods: This study included 175 patients with heart failure undergoing right heart catheterization to evaluate candidacy for advanced therapies and 21 healthy controls. we modified a single-beat approach to elastance to account for the magnitude of pulmonary arterial pressure and estimated right ventricular end-systolic elastance (e), pulmonary arterial elastance (e), and the e:e ratio. we defined elevated pulmonary arterial load as an e > 0.5 mm hg/ml, and ventriculo-arterial uncoupling as an e:e 0.5 mm hg/ml. e:e was lower in patients than in controls (p < 0.001), and 47% of the patients demonstrated e:e < 0.8, including 8% with normal e. in median follow-up of 2.2 (0.8-4.6) years, 53 died, 37 received cardiac transplantation, and 33 received a left ventricular assist device. by multivariable analysis, e (hazard ratios [hr]: 2

Who reads Elevated Pulmonary Arterial Elastance And Right Ventricular Uncoupling Are Associated With Greater Mortality In Advanced Heart Failure?

Author

Wright, Stephen P.; Groves, Leah; Vishram-Nielsen, Julie K.K.; Karvasarki, Elizabeth; Valle, Felipe H.; Alba, Ana C.; Mak, Susanna

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1557-3117)

Published

2020

Language

EN

Field

Medicine (Health Sciences)