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Thin Film Multi-Electrode Softening Cuffs for Selective Neuromodulation by María A. González-González; Aswini Kanneganti; Alexandra Joshi-Imre; Ana G. Hernandez-Reynoso; Geetanjali Bendale; Romil Modi; Melanie Ecker; Ali Khurram; Stuart F. Cogan; Walter E. Voit; Mario I. Romero-Ortega is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Thin Film Multi-Electrode Softening Cuffs for Selective Neuromodulation about?
## Abstract Silicone nerve cuff electrodes are commonly implanted on relatively large and accessible somatic nerves as peripheral neural interfaces. While these cuff electrodes are soft (1–50 MPa), their self-closing mechanism requires of thick walls (200–600 μm), which in turn contribute to fibrotic tissue growth around and inside the device, compromising the neural interface. We report the use of thiol-ene/acrylate shape memory polymer (SMP) for the fabrication of thin film multi-electrode softening cuffs (MSC). We fabricated multi-size MSC with eight titanium nitride (TiN) electrodes ranging from 1.35 to 13.95 × 10^−4^ cm^2^ (1–3 kΩ) and eight smaller gold (Au) electrodes (3.3 × 10^−5^ cm^2^; 750 kΩ), that soften at physiological conditions to a modulus of 550 MPa. While the SMP material is not as soft as silicone, the flexural forces of the SMP cuff are about 70–700 times lower in the MSC devices due to the 30 μm thick film compared to the 600 μm thick walls of the silicone cuffs. We demonstrated the efficacy of the MSC to record neural signals from rat sciatic and pelvic nerves (1000 μm and 200 μm diameter, respectively), and the selective fascicular stimulation by current ste
Who reads Thin Film Multi-Electrode Softening Cuffs for Selective Neuromodulation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- María A. González-González; Aswini Kanneganti; Alexandra Joshi-Imre; Ana G. Hernandez-Reynoso; Geetanjali Bendale; Romil Modi; Melanie Ecker; Ali Khurram; Stuart F. Cogan; Walter E. Voit; Mario I. Romero-Ortega
- Publisher
- Springer Science and Business Media LLC
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)