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Induction of Systemic Immunity by Expression of Interleukin-23 in Murine Colon Carcinoma Cells by Yan-Qing Wang; Shin-ichi Ugai; Osamu Shimozato; Ling Yu; Kiyoko Kawamura; Hiroshi Yamamoto; Taketo Yamaguchi; Hiromitsu Saisho; Masatoshi Tagawa is a Medicine article available to read on EtoBox.
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## Abstract Interleukin‐23 (IL‐23), a novel cytokine composed of a newly identified p19 molecule and the p40 subunit of IL‐12, can stimulate the proliferation __in vitro__ of memory T cells. We examined whether Colon 26 murine colon carcinoma cells that were retrovirally transduced with the __p19__‐linked __p40__ gene (Colon 26/IL‐23) could produce antitumor effects in inoculated mice. The growth of Colon 26/IL‐23 tumors developed in immunocompetent mice was significantly retarded and the tumors disappeared thereafter. Spleen cells from the mice that received Colon 26/IL‐23 cells produced significant amounts of interferon‐γ, when they were cultured with irradiated Colon 26 but not irrelevant cells. Depletion of CD8^+^ T cells suppressed the production of interferon‐γ. The mice that had rejected Colon 26/IL‐23 tumors were resistant to subsequent challenge of parent but not irrelevant tumor cells. Colon 26/IL‐23 tumors were not rejected in nude mice but the growth was retarded compared to parent tumors. Treatment of nude mice with anti‐asialo GM~1~ antibody did not influence the growth of Colon 26/IL‐23 tumors. These data suggest that expression of IL‐23 in tumors produces T cell‐dep
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- Author
- Yan-Qing Wang; Shin-ichi Ugai; Osamu Shimozato; Ling Yu; Kiyoko Kawamura; Hiroshi Yamamoto; Taketo Yamaguchi; Hiromitsu Saisho; Masatoshi Tagawa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)