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Can I read Hexachlorocyclohexane Differentially Alters the Antioxidant Status of the Brain Regions in Rat on EtoBox?
Hexachlorocyclohexane Differentially Alters the Antioxidant Status of the Brain Regions in Rat by Anup Srivastava; T. Shivanandappa is a Environmental Science article available to read on EtoBox.
What is Hexachlorocyclohexane Differentially Alters the Antioxidant Status of the Brain Regions in Rat about?
Hexachlorocyclohexane (HCH), a highly persistent organochlorine insecticide, is neurotoxic at acute doses and causes degenerative effects on chronic exposure. HCH has been reported to induce oxidative stress in cells and tissues. Mammalian brain is sensitive to oxidative stress which is implicated in neurodegenerative diseases. Effect of HCH on the brain regions, cortex, cerebellum, midbrain and brainstem, has been investigated by studying the response of antioxidant enzymes in rats treated orally with HCH at 25 and 100mg/kg b.w. for 2 weeks. Lipid peroxidation and glutathione depletion was seen in all the brain regions of HCH treated rats. The brain regions showed distinct variation in the antioxidant enzyme activities. Activities of glutathione peroxidase, glutathione reductase, glutathione-S-transferase and catalase were markedly induced whereas superoxide dismutase was inhibited at higher dose in all the brain regions. Marked induction and inhibition of the antioxidant enzymes, especially in the cortex and to varying degrees in other brain regions, was seen in HCH treated rats. These biochemical changes suggest vulnerability to oxidative stress in the brain is region-specific.
Who reads Hexachlorocyclohexane Differentially Alters the Antioxidant Status of the Brain Regions in Rat?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Anup Srivastava; T. Shivanandappa
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)
- Published
- 2005
- Language
- EN
- Field
- Environmental Science (Life Sciences)