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Primary Aldosteronism in a Patient With an Adrenal Macroadenoma and Clinically Important Cortisol Cosecretion by William Young; Irina Bancos is a book available to read on EtoBox.

What is Primary Aldosteronism in a Patient With an Adrenal Macroadenoma and Clinically Important Cortisol Cosecretion about?

Unlike aldosterone-producing adenomas (APAs) that can be 2 cm in diameter). Thus when a patient with PA has a large adrenal adenoma (>1.5 cm), clinicians should screen for cortisol cosecretion. If autonomous cortisol cosecretion is present in a patient with PA who has a unilateral adrenal macroadenoma, then adrenal venous sampling (AVS) is not needed. Usually in this setting the macroadenoma is cosecreting aldosterone and cortisol. However, even if the patient has PA caused by bilateral idiopathic hyperplasia (IHA) or a contralateral adrenal microadenoma, we do not have a good long-term viable medical treatment option for hypercortisolism, whereas mineralocorticoid receptor antagonists are an excellent treatment option for PA if it proves to persist following unilateral adrenalectomy. Thus if AVS is performed in the setting described in the preceding text, the findings do not guide surgical management.

Author

William Young; Irina Bancos

Publisher

Elsevier

Published

2023

Language

EN