Can I read Diabetes Drug Effects on the Skeleton on EtoBox?

Diabetes Drug Effects on the Skeleton by Manju Chandran is a Medicine article available to read on EtoBox.

What is Diabetes Drug Effects on the Skeleton about?

Diabetes be it type 1 or type 2 is associated with an increased risk of fragility fractures. The mechanisms underlying this increased risk are just being elucidated. Anti-diabetes medications are crucial for maintaining glucose control and for preventing micro-and macrovascular complications in diabetes. However, they may modulate fracture risk in diabetes in different ways. Thiazolidinediones have demonstrated an unfavorable effect on the skeleton, while metformin and sulfonylureas may have a neutral if not beneficial effect on bone. The use of insulin has been associated with an increased risk of fragility fractures though it is not clear whether it is due to direct influence of insulin or whether it is mediated through hypoglycemia and increased falls risk. The overall effect of incretin mimetics appears to be beneficial; however, this has to be elucidated further. The bone effects of pramlintide, a synthetic analog of amylin, have not been explored fully. Finally, issues regarding bone safety of SGLT2 (sodium-dependent glucose transporter 2) inhibitors, the newest anti-diabetic medications on the market are of concern. The purpose of this review is to provide a comprehensive ov

Who reads Diabetes Drug Effects on the Skeleton?

Author

Manju Chandran

Publisher

Springer Science and Business Media LLC

Published

2016

Language

EN

Field

Medicine (Health Sciences)