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What is Methylation Aging Clock Overview about?

This document summarizes a new pan-tissue methylation aging clock model that was developed using methylation data from over 4,600 samples across 21 different tissues and cell types. The clock was trained using elastic net regression on two-thirds of the data and achieved strong performance, with an R2 of 0.99 on the training set and 0.97 on the held-out test set. Key pathways enriched in the clock CpGs were found to be development-related. Comparison to known aging genes found 97 were common between the mod

Author

Karthikeyan AV

Language

EN