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Antiepileptic Drugs in Migraine Prevention by Ninan T. Mathew is a Medicine article available to read on EtoBox.

What is Antiepileptic Drugs in Migraine Prevention about?

Migraineurs may continue to experience attacks, despite daily use of one or more agents from a wide range of drugs, including **β**‐blockers, calcium channel blockers, serotonin antagonists, tricyclic antidepressants, monoamine oxidase inhibitors, and antiepileptic agents. Divalproex sodium is the only antiepileptic drug approved for migraine prevention. Gabapentin, topiramate, and other antiepileptic agents are being evaluated for migraine prevention and treatment. Prospective, double‐blind, placebo‐controlled clinical trials of divalproex, gabapentin, and topiramate for migraine prevention generally were composed of a prospective baseline period, a dose titration period, and a fixed‐dose treatment period. The primary efficacy variable was a reduction in the 28‐day frequency of migraine headache. Patients receiving divalproex for 12 weeks at doses up to 1500 mg/day achieved significant decreases in the migraine frequency (__P__**<**.05), corresponding to reductions of 30% to 40% compared with baseline. Nearly half of the divalproex‐treated patients had a 50% or more reduction from baseline in headache frequencies (__P__.05). Asthenia, vomiting, somnolence, tremor, and alopecia wer

Who reads Antiepileptic Drugs in Migraine Prevention?

Author

Ninan T. Mathew

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0017-8748)

Published

2001

Language

EN

Field

Medicine (Health Sciences)