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A Comparison of Pregabalin, Lamotrigine, and Placebo as Adjunctive Therapy in Patients with Refractory Partial-onset Seizures by Michel Baulac; Teresa Leon; Terence J. O’Brien; Edward Whalen; Jeannette Barrett is a Medicine article available to read on EtoBox.

What is A Comparison of Pregabalin, Lamotrigine, and Placebo as Adjunctive Therapy in Patients with Refractory Partial-onset Seizures about?

Purpose: This study assessed the comparative efficacy of pregabalin for refractory partial seizures. Methods: Four-hundred and thirty-four patients with partial seizures were randomized to pregabalin, lamotrigine, or placebo as adjunctive therapy for 17 weeks of double-blind treatment. In phase I (11 weeks), pregabalin was titrated over 1 week and lamotrigine over 5 weeks to fixed dosages of 300 mg/day for both. In phase II (6 weeks), patients not yet seizure-free were increased to pregabalin 600 mg/day or lamotrigine 400 mg/day. Results: During phase I, there was a nonsignificant trend toward a greater reduction in seizures with pregabalin versus placebo and lamotrigine. Across the 17 weeks of treatment, pregabalin showed a median percentage reduction from baseline in seizure frequency of -20.0% (p = .001) versus placebo, and -9.7% (p = .080) versus lamotrigine. The responder rate (≥50% reduction in seizure frequency) for pregabalin exceeded that of placebo (36% vs 21%; p = .007) and lamotrigine (36% vs 24%; p = .04). Adverse events were consistent with the known safety profiles of pregabalin and lamotrigine.

Who reads A Comparison of Pregabalin, Lamotrigine, and Placebo as Adjunctive Therapy in Patients with Refractory Partial-onset Seizures?

Author

Michel Baulac; Teresa Leon; Terence J. O’Brien; Edward Whalen; Jeannette Barrett

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2010

Language

EN

Field

Medicine (Health Sciences)