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Luminescent Chitosan/carbon Dots as an Effective Nano-drug Carrier for Neurodegenerative Diseases† by Sheril Ann Mathew; P. Praveena; S. Dhanavel; R. Manikandan; S. Senthilkumar; A. Stephen is a Materials Science article available to read on EtoBox.

What is Luminescent Chitosan/carbon Dots as an Effective Nano-drug Carrier for Neurodegenerative Diseases† about?

Designing new materials for effective and targeted drug delivery is pivotal in biomedical research. Herein, we report on the development of a chitosan/carbon dot-based nanocomposite and investigate its efficacy as a carrier for the sustained release of dopamine drug. The carbon dots (CDs) were synthesized from the carbonization of chitosan and were further conjugated with chitosan (CS) to obtain a chitosan/carbon dot (CS/CD) matrix. Dopamine was later encapsulated in the matrix to form a dopamine@CS/CD nanocomposite. The cytotoxicity of IC-21 and SH-SY5Y cell lines was studied at various concentrations of the nanocomposite and the results demonstrate around 97% cell viability. The photoluminescence property revealed the characteristic property of the carbon dots. When excited at 510 nm an emission peak was observed at 550 nm which enables the use of carbon dots as a tracer for bioimaging. The HRTEM images and the D, G, and 2D bands of the Raman spectra confirm the successful synthesis of carbon dots and through DLS the particle size is estimated to be ∼3 nm. The release studies of the encapsulated drug from the composite were analyzed in an __in vitro__ medium at different pH level

Who reads Luminescent Chitosan/carbon Dots as an Effective Nano-drug Carrier for Neurodegenerative Diseases†?

Author

Sheril Ann Mathew; P. Praveena; S. Dhanavel; R. Manikandan; S. Senthilkumar; A. Stephen

Publisher

The Royal Society of Chemistry

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)