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Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac ( Rhus chinensis Mill.) fruits by oral administration in rats by Wu, Zihuan; Ma, Yanli; Zhao, Lei; Cai, Shengbao; Cheng, Guiguang is a Medicine article available to read on EtoBox.

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In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as

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Author

Wu, Zihuan; Ma, Yanli; Zhao, Lei; Cai, Shengbao; Cheng, Guiguang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0278-6915)

Published

2018

Language

EN

Field

Medicine (Life Sciences)