Can I read The impacts of curcumin on learning memory function in Alzheimer’s disease under the poly lactic-co-glycolic acid nanoparticle drug carrier on EtoBox?

The impacts of curcumin on learning memory function in Alzheimer’s disease under the poly lactic-co-glycolic acid nanoparticle drug carrier by Hongmei Zeng; Lijun Xu; Yeqing Zou; Sixiang Wang is a Materials Science article available to read on EtoBox.

What is The impacts of curcumin on learning memory function in Alzheimer’s disease under the poly lactic-co-glycolic acid nanoparticle drug carrier about?

To analyze the treatment effect of the curcumin nanoparticle drug delivery system to the Alzheimer's disease (AD), the NP-Cur, NP-S1-Cur, and NP-S1-Cur-CRT nanoparticles were prepared by combining the various internal water phases based on the emulsification volatilization method for the cytotoxicity test and applied to treatment of β-amyloid precursor protein/ pistilloid-stamen 1 (APP/PS1) double transgenic (DT) mice in three groups, which were group W1 (treated with NP-Cur), W2 (treated with NP-S1-Cur), W3 (treated with NP-S1-Cur-CRT), W4 (treated with curcumin drugs), and W0 (normal control), respectively. Immunohistochemistry was adopted to detect the senile plaques (amyloid precursor antibody, 6E10), microglia (IBA-1), and astrocytes (glial fibrillary acidic protein, GFAP). The spatial memory ability (SMA) of mice was evaluated by the Y maze experiment, and the learning memory ability (LMA) of mice was evaluated by the new thing cognition experiment. The results showed that in the human neuroblastoma cell (SH-SY5Y), mouse brain microvascular endothelial cell line (bEnd.3), and mouse microglia cell line (BV2), the cell activity (CA) caused by NP-Cur, NP-S1-Cur, and NP-S1-Cur-CR

Who reads The impacts of curcumin on learning memory function in Alzheimer’s disease under the poly lactic-co-glycolic acid nanoparticle drug carrier?

Author

Hongmei Zeng; Lijun Xu; Yeqing Zou; Sixiang Wang

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)