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The Contribution of the Capillary Endothelium to Blood Clearance and Tissue Deposition of Anionic Quantum Dots in Vivo by Marc Praetner; Markus Rehberg; Peter Bihari; Max Lerchenberger; Bernd Uhl; Martin Holzer; Martin E. Eichhorn; Robert Fürst; Tamara Perisic; Christoph A. Reichel; Ulrich Welsch; Fritz Krombach is a Engineering article available to read on EtoBox.

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The increasing interest in biomedical applications of semiconductor quantum dots (QDs) is closely linked to the use of surface modifications to target specific sites of the body. The immense surface area of vascular endothelium is a possible interaction platform with systemically administered QDs. Therefore, the aim of this study was to investigate the microvascular distribution of neutral, cationic, and anionic QDs in vivo. QDs with carboxyl-, amine-and polyethylene glycol surface coatings were injected into the blood circulation of mice. In vivo microscopy of the cremaster muscle, two-photon microscopy of skeletal and heart muscle, as well as quantitative fluorescence measurements of blood, excreta, and tissue samples were performed. Transmission electron microscopy was used to detect QDs at the cellular level. The in vitro association of QDs with cultured endothelial cells was investigated by flow cytometry and confocal microscopy. Anionic QDs exhibited a very low residence time in the blood stream, preferably accumulated in organs with a prominent mononuclear phagocytic component, but were also found in other tissues with low phagocytic properties where they were predominantly

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Author

Marc Praetner; Markus Rehberg; Peter Bihari; Max Lerchenberger; Bernd Uhl; Martin Holzer; Martin E. Eichhorn; Robert Fürst; Tamara Perisic; Christoph A. Reichel; Ulrich Welsch; Fritz Krombach

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)