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Genotype variation of ACE and ACE2 genes affects the severity of COVID-19 patients by Ingrid Faustine; Deli Marteka; Amarila Malik; Eko Supriyanto; Nadia F. Syafhan is a Medicine article available to read on EtoBox.

What is Genotype variation of ACE and ACE2 genes affects the severity of COVID-19 patients about?

## Objective Genetic polymorphisms in __ACE__ and __ACE2__ genes are involved in the RAS regulation of blood pressure and their activity may confer susceptibility to hypertension. In addition, they may play a role in SARS-CoV-2 pathogenesis and the severity of COVID-19. This study aims to determine the effect of genetic variations in the __ACE__ (rs4331) and __ACE2__ (rs2074192) genes with hypertension comorbidity on the severity of COVID-19 in the Indonesian population. ## Result 186 patients were enrolled and assigned into the COVID-19 group (n = 95) and non-COVID-19 group (n = 91) in this cross-sectional study. GG genotype frequency was dominant in __ACE__ gene, but there were no significant differences between the groups (p = 0.163). The two groups had a significant difference (p = 0.000) for the CC genotype frequency (0,37 vs. 0.01) in the __ACE2__ gene. The proportion of women with COVID-19 is higher (51%), but men with hypertension had more severe symptoms (44%). Men with hypertension comorbidity, GG (__ACE__), and TT (__ACE2__) genotypes tended to have moderate-to-severe symptoms (25%). Similarly, women with hypertension as well as GG and CT genotypes tended to have moderat

Who reads Genotype variation of ACE and ACE2 genes affects the severity of COVID-19 patients?

Author

Ingrid Faustine; Deli Marteka; Amarila Malik; Eko Supriyanto; Nadia F. Syafhan

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)