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Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii by Kuniyoshi Shimizu; Maiko Yamanaka; Mayumi Gyokusen; Shuhei Kaneko; Mototake Tsutsui; Junichi Sato; Ikuo Sato; Masao Sato; Ryuichiro Kondo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract In the course of a search for natural estrogen‐like materials from mushrooms, the proliferating effects of the methanol extracts of 14 edible mushrooms on the estrogen‐dependent growth of MCF‐7 cells were examined. Of the extracts, that from the fruiting body of __Pleurotus eryngii__ showed the strongest estrogen‐like activity, specifically on the proliferating effects of MCF‐7 cells. This proliferation effect of the extract from the fruiting body of __P. eryngii__ is related to its estrogenic activity, because this proliferation activity was inhibited by the addition of the antiestrogenic compound ICI 182 780. The ethanol extract of the fruiting body of __P. eryngii__ prevented ovariectomy‐induced bone loss. The present data provide evidence that the ethanol extract of __P. eryngii__ helps to protect against the bone loss caused by estrogen deficiency, without having a substantial effect on the uterus. Copyright © 2006 John Wiley & Sons, Ltd.

Who reads Estrogen-like activity and prevention effect of bone loss in calcium deficient ovariectomized rats by the extract of Pleurotus eryngii?

Author

Kuniyoshi Shimizu; Maiko Yamanaka; Mayumi Gyokusen; Shuhei Kaneko; Mototake Tsutsui; Junichi Sato; Ikuo Sato; Masao Sato; Ryuichiro Kondo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-418X)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)