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What is Effects of Iloperidone Weaning in Rodents about?

This document reviews the behavioural and neurochemical effects of post-weaning social isolation in rodents. It finds that social isolation leads to reproducible long-term changes including neophobia, impaired sensorimotor gating, aggression, cognitive rigidity, reduced prefrontal cortical volume and decreased synaptic plasticity in the cortex and hippocampus. These alterations are associated with hyperfunction of mesolimbic dopamine systems and enhanced dopamine and serotonin function in the nucleus accumb

Author

Nityananda Portellada

Language

EN