About this Psychology article
Comparative efficacy and acceptability of first-line drugs for the acute treatment of generalized anxiety disorder in adults: A network meta-analysis by Hairong He; Yutao Xiang; Fengjie Gao; Ling Bai; Fan Gao; Yajuan Fan; Jun Lyu; Xiancang Ma is a Psychology article available to read on EtoBox.
The guide recommends SSRI and SNRI drugs as first-line treatments for generalized anxiety disorder (GAD). Therefore, we aimed to update the evidence using network meta-analysis by comparing the efficacy and acceptability of first-line drugs. The relevant electronic databases were searched for placebo-controlled and headto-head trials of 11 drugs used for the acute treatment of adults with GAD from 1980 up to January 1, 2019. Data on demographics, clinical, and treatment information were extracted from each eligible study. The primary outcomes were efficacy (quantified as the change in the total score on the Hamilton Anxiety Scale from baseline) and acceptability (quantified as treatment discontinuations due to any cause). Overall, the data on 41 RCTs were sufficient or appropriate for inclusion. In terms of efficacy, all of the drugs except fluoxetine and vortioxetine were more effective than placebo, with the weighted mean difference of the Hamilton Anxiety Scale score ranging between -3.2 (95% credible interval [CrI] = -4.2 to -2.2) for escitalopram and -1•8 (95% CrI = -3.1 to -0.55) for vilazodone. For acceptability, only vilazodone (OR = 1.7, 95% CrI = 1.1 to 2.7) were worse th
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- Author
- Hairong He; Yutao Xiang; Fengjie Gao; Ling Bai; Fan Gao; Yajuan Fan; Jun Lyu; Xiancang Ma
- Published
- 2019
- Language
- EN
- Field
- Psychology (Social Sciences)