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Can I read Dantrolene Can Reduce Secondary Damage After Spinal Cord Injury on EtoBox?
Dantrolene Can Reduce Secondary Damage After Spinal Cord Injury by Adem Aslan; Mustafa Cemek; Mehmet Emin Buyukokuroglu; Korhan Altunbas; Orhan Bas; Yusuf Yurumez; Murat Cosar is a Medicine article available to read on EtoBox.
What is Dantrolene Can Reduce Secondary Damage After Spinal Cord Injury about?
The aim of this experimental study was to investigate the possible protective effects of dantrolene on traumatic spinal cord injury (SCI). Twenty-four New Zealand rabbits were divided into three groups: Sham (no drug or operation, n = 8), Control (SCI ? 1 mL saline intraperitoneally (i.p.), n = 8), and DNT (SCI ? 10 mg/kg dantrolene in 1 mL, i.p., n = 8). Laminectomy was performed at T10 and balloon catheter was applied extradurally. Four and 24 h after surgery, rabbits were evaluated according to the Tarlov scoring system. Blood, cerebrospinal fluid and tissue sample from spinal cord were taken for measurements of antioxidant status or detection of apoptosis. After 4 h SCI, all animals in control or DNT-treated groups became paraparesic. Significant improvement was observed in DNT-treated group, 24 h after SCI, with respect to control. Traumatic SCI led to an increase in the lipid peroxidation and a decrease in enzymic or non-enzymic endogenous antioxidative defense systems, and increase in apoptotic cell numbers. DNT treatment prevented lipid peroxidation and augmented endogenous enzymic or non-enzymic antioxidative defense systems. Again, DNT treatment significantly decreased th
Who reads Dantrolene Can Reduce Secondary Damage After Spinal Cord Injury?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Adem Aslan; Mustafa Cemek; Mehmet Emin Buyukokuroglu; Korhan Altunbas; Orhan Bas; Yusuf Yurumez; Murat Cosar
- Publisher
- Springer Science and Business Media LLC
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)