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Comparison of Physicochemical Properties of Native Mucus and Reconstituted Mucin Gels by Caroline E. Wagner; Miri Krupkin; Kathryn B. Smith-Dupont; Chloe M. Wu; Nicole A. Bustos; Jacob Witten; Katharina Ribbeck is a Materials Science article available to read on EtoBox.

What is Comparison of Physicochemical Properties of Native Mucus and Reconstituted Mucin Gels about?

Simulating native mucus with model systems such as gels made from reconstituted mucin or commercially available polymers presents experimental advantages including greater sample availability and reduced inter-and intradonor heterogeneity. Understanding whether these gels reproduce the complex physical and biochemical properties of native mucus at multiple length scales is critical to building relevant experimental models, but few systematic comparisons have been reported. Here, we compared bulk mechanical properties, microstructure, and biochemical responses of mucus from different niches, reconstituted mucin gels (with similar pH and polymer concentrations as native tissues), and commonly used commercially available polymers. To evaluate gel properties across these length scales, we used small-amplitude oscillatory shear, single-particle tracking, and microaffinity chromatography with small analytes. With the exception of human saliva, the mechanical response of mucin gels was qualitatively similar to that of native mucus. The transport behavior of charged peptides through native mucus gels was qualitatively reproduced in gels composed of corresponding isolated mucins. Compared t

Who reads Comparison of Physicochemical Properties of Native Mucus and Reconstituted Mucin Gels?

Author

Caroline E. Wagner; Miri Krupkin; Kathryn B. Smith-Dupont; Chloe M. Wu; Nicole A. Bustos; Jacob Witten; Katharina Ribbeck

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)