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A Meta‐analysis of the Neurocognitive Sequelae of Treatment for Childhood Acute Lymphocytic Leukemia by Laura K. Campbell; Mary Scaduto; William Sharp; Lynette Dufton; Deborah Van Slyke; James A. Whitlock; Bruce Compas is a Medicine article available to read on EtoBox.
What is A Meta‐analysis of the Neurocognitive Sequelae of Treatment for Childhood Acute Lymphocytic Leukemia about?
## Abstract ## Background Impaired neurocognitive functioning is one increasingly recognized long‐term consequence of childhood ALL treatment. However, research findings have been inconsistent regarding the domains affected and the degree to which they are compromised. ## Procedure A comprehensive meta‐analytic review of the long‐term neurocognitive effects of childhood ALL was conducted. Studies were included if they were published in English, reported original quantitative data on the post‐treatment neurocognitive functioning of childhood ALL patients in first remission and control groups, and used neurocognitive measures with adequate psychometric properties and published normative data. ## Results Data from 28 empirical studies yielding 13 effect sizes across nine domains were extracted and analyzed. All effects were negative (__g__ = −0.34 to −0.71), demonstrating that ALL survivors consistently experienced significant deficits in intellectual functioning, academic achievement, and specific neurocognitive abilities compared to control groups. The role of potential moderators, including treatment with cranial irradiation, age at time of diagnosis, and time since treatment ended
Who reads A Meta‐analysis of the Neurocognitive Sequelae of Treatment for Childhood Acute Lymphocytic Leukemia?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Laura K. Campbell; Mary Scaduto; William Sharp; Lynette Dufton; Deborah Van Slyke; James A. Whitlock; Bruce Compas
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)