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Effects of Liquid Chromatography Mobile Phases and Buffer Salts on Phosphorus Inductively Coupled Plasma Atomic Emission and Mass Spectrometries Utilizing Ultrasonic Nebulization and Membrane Desolvation by John E. Carr; Kaho Kwok; Gregory K. Webster; Jon W. Carnahan is a Chemistry article available to read on EtoBox.

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Atomic spectrometry, specifically inductively coupled plasma atomic emission spectrometry (ICP-AES) and mass spectrometry (ICP-MS) show promise for heteroatom-based detection of pharmaceutical compounds. The combination of ultrasonic nebulization (USN) with membrane desolvation (MD) greatly enhances detection limits with these approaches. Because pharmaceutical analyses often incorporate liquid chromatography, the study herein was performed to examine the effects of solvent composition on the analytical behaviors of these approaches. The target analyte was phosphorus, introduced as phosphomycin. AES response was examined at the 253.7 nm atom line and mass 31 ions were monitored for the MS experiments. With pure aqueous solutions, detection limits of 5 ppb (0.5 ng in 0.1 mL injection volumes) were obtained with ICP-MS. The ICP-AES detection limit was 150 ppb. Solvent compositions were varied from 0 to 80% organic (acetonitrile and methanol) with nine buffers at concentrations typically used in liquid chromatography. In general, solvents and buffers had statistically significant, albeit small, effects on ICP-AES sensitivities. A few exceptions occurred in cases where typical liquid c

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Author

John E. Carr; Kaho Kwok; Gregory K. Webster; Jon W. Carnahan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)

Published

2006

Language

EN

Field

Chemistry (Physical Sciences)